Gene-to-gene transcriptional coordination breakdown among single cells during aging
Visiting speaker
Orr Levy
Postdoctoral Associate, Yale University, New Haven, Connecticut
Past Talk
Wednesday
Sep 28, 2022
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2:30 pm
177 Huntington Ave
Virtual
11th floor
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A long-standing paradigm holds that stochastic aberrations of transcriptional regulation play a key role in the process of aging. While transcriptional dysregulation is observed in the majority of cell types in the form of increased cell-to-cell variability, its generality to all cell types remains doubted. Here, a novel approach is proposed for analyzing transcriptional regulation in single-cell RNA sequencing (scRNA-seq) data by focusing on the global coordination between the genes rather than the variability of individual genes or correlations between pairs of genes. Consistently, across different organisms and cell types, a decrease in the gene-to-gene transcriptional coordination is found in aging cells. In addition, loss of gene-to-gene transcriptional coordination is associated with a high mutational load of a specific, age-related signature and with radiation-induced DNA damage. These observations suggest a general, potentially universal, stochastic attribute of transcriptional dysregulation in aging.

About the speaker
About the speaker
Orr Levy is a postdoctoral associate in the lab of Professor Ruslan Medzhitov at Yale University. Orr's postdoc study is in the field of complex networks, focusing on problems from biology and physiology. He has prior research experience both at Bar-Ilan University under the supervision of Professor Shlomo Havlin, and prior research and management experience in the Israeli high-tech industry as a head of C4I branch, in charge of data mining, data engineering, and systems architecture.
Orr Levy is a postdoctoral associate in the lab of Professor Ruslan Medzhitov at Yale University. Orr's postdoc study is in the field of complex networks, focusing on problems from biology and physiology. He has prior research experience both at Bar-Ilan University under the supervision of Professor Shlomo Havlin, and prior research and management experience in the Israeli high-tech industry as a head of C4I branch, in charge of data mining, data engineering, and systems architecture.