Biological networks

role of cellular and sub-cellular connections in biological function and disease

This work focuses on building theoretically driven models of genetic, cellular and protein interactions to understand the role of connectivity in function, regulation and disease. By mapping structural relations across pheno and genotypic features of biological systems, we aim to build entirely new paradigms of biological interactions that will dramatically improve disease prevention strategies.

Featured publications

Nutrient concentrations in food display universal behaviour

Giulia Menichetti & Albert-László Barabási
Nature Food
May 24, 2022

A computational exploration of resilience and evolvability of protein–protein interaction networks

Brennan Klein, Ludvig Holmér, Keith M. Smith, Mackenzie M. Johnson, Anshuman Swain, Laura Stolp, Ashley I. Teufel & April S. Kleppe.
Communications Biology
December 2, 2021

The effective graph reveals redundancy, canalization, and control pathways in biochemical regulation and signaling

Alexander J. Gates, Rion Brattig Correia, Xuan Wang, Luis M. Rocha
March 23, 2021

Recent publications

Maximizing brain networks engagement via individualized connectome-wide target search

Arianna Menardi, Davide Momi, Antonino Vallesi, Albert-Laszlo Barabasi, Emma K. Towlson, Emiliano Santarnecchi
Brain Stimulation
October 13, 2022

MilkyBase, a database of human milk composition as a function of maternal-, infant- and measurement conditions

Tünde Pacza, Mayara L. Martins, Maha Rockaya, Katalin Müller, Ayan Chatterjee, Albert-László Barabási, József Baranyi
Scientific Data
September 9, 2022

Research gaps and opportunities in precision nutrition: an NIH workshop report

Bruce Y Lee, José M Ordovás, Elizabeth J Parks, Cheryl A M Anderson, Albert-László Barabási, Steven K Clinton, Kayla de la Haye, Valerie B Duffy, Paul W Franks, Elizabeth M Ginexi, Kristian J Hammond, Erin C Hanlon, Michael Hittle, Emily Ho, Abigail L Horn, Richard S Isaacson, Patricia L Mabry, Susan Malone, Corby K Martin, Josiemer Mattei, Simin Nikbin Meydani, Lorene M Nelson, Marian L Neuhouser, Brendan Parent, Nicolaas P Pronk, Helen M Roche, Suchi Saria, Frank A J L Scheer, Eran Segal, Mary Ann Sevick, Tim D Spector, Linda Van Horn, Krista A Varady, Venkata Saroja Voruganti, Marie F Martinez
The American Journal of Clinical Nutrition
September 2, 2022

Nutrient concentrations in food display universal behaviour

Giulia Menichetti & Albert-László Barabási
Nature Food
May 24, 2022

Evolution and emergence: higher order information structure in protein interactomes across the tree of life

Brennan Klein, Erik Hoel, Anshuman Swain, Ross Griebenow, Michael Levin
Oxford Academic
December 22, 2021
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Featured project

The Foodome project aims to understand environmental components of coronary heart disease (CHD). The goal is to categorize food ingredients into their chemical constituents in order to identify precise chemical mechanisms that explain how ingested chemicals lead to CHD. The project will take on an immense data collection effort tracking food intake across large populations to capture individualized chemical palettes and determine stability of individuals’ food fingerprint over time. This work will result in the first ever database cataloging an exhaustive list of chemicals that humans consume, which will be used to explore complex relationships between food intake and disease risk.

Associated faculty

Major funders

American Heart Association, NSF, NIH