Biological networks

role of cellular and sub-cellular connections in biological function and disease

This work focuses on building theoretically driven models of genetic, cellular and protein interactions to understand the role of connectivity in function, regulation and disease. By mapping structural relations across pheno and genotypic features of biological systems, we aim to build entirely new paradigms of biological interactions that will dramatically improve disease prevention strategies.

Featured publications

The effective graph reveals redundancy, canalization, and control pathways in biochemical regulation and signaling

Alexander J. Gates, Rion Brattig Correia, Xuan Wang, Luis M. Rocha
PNAS
March 23, 2021

Network medicine framework shows that proximity of polyphenol targets and disease proteins predicts therapeutic effects of polyphenols

Italo F. do Valle, Harvey G. Roweth, Michael W. Malloy, Sofia Moco , Denis Barron, Elisabeth Battinelli, Joseph Loscalzo, Albert-László Barabási 
Nature Food
March 19, 2021

A systematic comprehensive longitudinal evaluation of dietary factors associated with acute myocardial infarction and fatal coronary heart disease

Soodabeh Milanlouei, Giulia Menichetti, Yanping Li, Joseph Loscalzo, Walter C. Willett & Albert-László Barabási
Nature Communications
November 27, 2020

Recent publications

The effective graph reveals redundancy, canalization, and control pathways in biochemical regulation and signaling

Alexander J. Gates, Rion Brattig Correia, Xuan Wang, Luis M. Rocha
PNAS
March 23, 2021

Network medicine framework shows that proximity of polyphenol targets and disease proteins predicts therapeutic effects of polyphenols

Italo F. do Valle, Harvey G. Roweth, Michael W. Malloy, Sofia Moco , Denis Barron, Elisabeth Battinelli, Joseph Loscalzo, Albert-László Barabási 
Nature Food
March 19, 2021

A systematic comprehensive longitudinal evaluation of dietary factors associated with acute myocardial infarction and fatal coronary heart disease

Soodabeh Milanlouei, Giulia Menichetti, Yanping Li, Joseph Loscalzo, Walter C. Willett & Albert-László Barabási
Nature Communications
November 27, 2020

Network Medicine Framework for Identifying Drug Repurposing Opportunities for COVID-19

Deisy Morselli Gysi, Ítalo Do Valle, Marinka Zitnik, Asher Ameli, Xiao Gan, Onur Varol, Susan Dina Ghiassian, JJ Patten, Robert Davey, Joseph Loscalzo, Albert-László Barabási
arXiv
August 9, 2020

Network Medicine Framework for Identifying Drug Repurposing Opportunities for COVID-19

Deisy Morselli Gysi, Ítalo Do Valle, Marinka Zitnik, Asher Ameli, Xiao Gan, Onur Varol, Susan Dina Ghiassian, JJ Patten, Robert Davey, Joseph Loscalzo, Albert-László Barabási
arXiv
April 15, 2020
View more

Featured project

The Foodome project aims to understand environmental components of coronary heart disease (CHD). The goal is to categorize food ingredients into their chemical constituents in order to identify precise chemical mechanisms that explain how ingested chemicals lead to CHD. The project will take on an immense data collection effort tracking food intake across large populations to capture individualized chemical palettes and determine stability of individuals’ food fingerprint over time. This work will result in the first ever database cataloging an exhaustive list of chemicals that humans consume, which will be used to explore complex relationships between food intake and disease risk.

Associated faculty

Major funders

American Heart Association, NSF, NIH