Clara Bay
PhD Student, Northeastern University
May 23, 2025
12:00 pm
May 23, 2025
12:00 pm
In-person
4 Thomas More St
London E1W 1YW, UK
London E1W 1YW, UK
The Roux Institute
Room
100 Fore Street
Portland, ME 04101
Portland, ME 04101
Network Science Institute
2nd floor
2nd floor
Network Science Institute
11th floor
11th floor
177 Huntington Ave
Boston, MA 02115
Boston, MA 02115
Network Science Institute
2nd floor
2nd floor
Room
58 St Katharine's Way
London E1W 1LP, UK
London E1W 1LP, UK
Talk recording
Epidemic models are used during infectious disease outbreaks to estimate disease parameters, examine the effect of interventions, and explore potential future outcomes. Predicting future disease trends can take the form of short-term forecasts or long-term scenario projections. Evaluating the performance of these projections is crucial for understanding their usefulness in guiding public health decision-making.
My dissertation aims to enhance methods for probabilistic epidemic model evaluation and scenario analysis. In my first chapter, I introduce the energy score as a robust metric for evaluating predictions in their native stochastic trajectory format. The project introduces the energy score in the context of epidemic modeling, and draws comparison with commonly used scores for model evaluation with applications to scenario projections. In my second project, I propose the scenario ensemble as a novel ensemble method for scenario projections, which combines results across scenario assumptions to easily communicate the range of potential future outcomes. Using 10 rounds of COVID-19 Scenario Modeling Hub data, we show well-calibrated projections and improved performance for the scenario ensemble of multi-model ensembles. In the third chapter, I take a step back to retrospectively evaluate the performance of infectious disease forecasting challenges over the past decade using a relative skill score to assess the evolution of disease forecasting performance over time, which will be essential for improving future infectious disease forecasts.
Generating and evaluating epidemic projections becomes more challenging in an emerging outbreak when surveillance is limited and disease properties are unknown. My fourth chapter aims to understand the controllability of global disease outbreaks through a theoretical scenario modeling exercise. I use a metapopulation network framework to describe the global spread of disease, with the goal of examining the impact of various public health interventions and disease characteristics on epidemic outcomes. Exploring the landscape of outbreak control is crucial for identifying effective responses in future emerging disease outbreaks.
About the speaker
Clara is a fourth-year Network Science PhD student in the MOBS Lab working with Professor Alessandro Vespignani. She is broadly interested in infectious disease modeling, and her research focuses on modeling with metapopulation networks, characterizing the controllability of global disease outbreaks, and evaluating the performance of epidemic predictions. Prior to joining the Network Science Institute, Clara worked as a research fellow at the U.S. EPA doing computational toxicology modeling research. She holds a B.S. in Applied Mathematics and Quantitative Biology from UNC Chapel Hill.
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