Kimberly Glass
London E1W 1YW, UK
Portland, ME 04101
2nd floor
11th floor
Boston, MA 02115
2nd floor
London E1W 1LP, UK
Talk recording
Understanding the complex structure of gene regulation, gene regulatory networks, and how those networks are altered in disease- and tissue- specific contexts, are all critical for developing effective, precision-medicine based therapeutic strategies. In addition, integrating multi-Omics data to effectively model biological networks has the potential to provide unprecedented insights into the mechanisms underlying disease. Along these lines, our group has developed a suite of computational approaches that support: (1) effectively integrating multi-Omic data to model gene regulatory networks; (2) performing network analysis to identify the biological mechanisms mediating changes in disease state; and (3) modeling patient-specific networks in order to link regulatory alterations with heterogeneous disease phenotypes in order to support precision medicine. In this talk, I will review several specific applications in which we have used these methods to discover new features of disease and to understand the complex regulatory processes at work across patients.