Roman Alpatov
London E1W 1YW, UK
Portland, ME 04101
2nd floor
11th floor
Boston, MA 02115
2nd floor
London E1W 1LP, UK
Talk recording
Epigenetics and epigenetic networks offer a novel and potentially groundbreaking platform for predictive analytics and biomarker discovery. Epigenetic analytic solutions extend beyond existing genomic technologies and represent a more predictive and dynamic biomarker discovery framework as compared to genomics because, unlike genomic biomarkers, epigenetic marks change very rapidly in response to environmental changes, drug therapies, and in disease. The dynamic and rapid epigenetic changes in response to a variety of stimuli allows early detection of patient responses to drug therapies as well as detection of early stages of disease. The first portion of the presentation will highlight my ideas for the potential applications of artificial intelligence technologies to characterize disease-specific epigenetic networks. The second portion of my talk will introduce exosomal histones as universal liquid biopsy-based epigenetic biomarkers and potential therapeutic targets relevant in immune-dysfunctional conditions such as rheumatoid arthritis and inflammatory bowel disease as well as inimmuno-oncology.