NetMedPy: A Python package for Large-Scale Network Medicine Screening

Andrés Aldana, Rodrigo Dorantes-Gilardi, Michael Sebek, Joseph Loscalzo, Albert-László Barabási, Giulia Menichetti
Bioinformatics
2025, btaf338
June 17, 2025
Network medicine leverages the quantification of information flow within sub-cellular networks to elucidate disease etiology and comorbidity, as well as to predict drug efficacy and identify potential therapeutic targets. However, current Network Medicine toolsets often lack computationally efficient data processing pipelines that support diverse scoring functions, network distance metrics, and null models. These limitations hamper their application in large-scale molecular screening, hypothesis testing, and ensemble modeling. To address these challenges, we introduce NetMedPy, a highly efficient and versatile computational package designed for comprehensive Network Medicine analyses.